10/27/2016 (09:00PM – 10:00PM) (Thursday) : DR. REESE GETS A RETURN VISIT FROM A TROUBLED YOUNG TEEN IN A SEEMINGLY HOPELESS SITUATION — SOPHIA BUSH GUEST STARS — Dr. Manning (Torrey DeVitto) tends to a young cancer patient and struggles to inform the parents of her dire condition. Elsewhere, Dr. Reese (Rachel DiPillo) gets contacted by Danny (guest star Nick Marini), the troubled young man, and turns to Dr. Charles (Oliver Platt) and Det. Lindsay (guest star Sophia Bush) for help in resolving a difficult situation. Goodwin (S. Epatha Merkerson) and Maggie (Marlyne Barrett) do their best to clear the logjam in the hospital and Dr. Rhodes (Colin Donnell) fine-tunes his instincts after both Dr. Latham (guest star Ato Assandoh) and Dr. Halstead (Nick Gehlfuss) pick up on things he doesn’t. Meanwhile, a teenage science geek and her friends impress Dr. Choi (Brian Tee) and Natalie with their bio-engineering lab. Yaya DaCosta also stars.
em>10/26/2016 (10:00PM – 11:00PM) (Wednesday) : AFTER THE BODY OF A COLLEGE STUDENT AND A BACKPACK FILLED WITH DEADLY FENTANYL WASH UP IN THE LAKE, INTELLIGENCE IS UNDER PRESSURE TO UNCOVER THE SOURCE OF THE DEADLY DRUG OPERATION. – Intelligence is tasked with tracking down the dealers of fentanyl – a drug that has been linked to multiple overdoses around the city. As they investigate possible sources, the team uncovers a series of dealers in a college smuggling ring. Meanwhile, Tay (guest star Li Jun Li) and Burgess (Marina Squerciati) come across a bloodied child who exposes a dark and twisted secret about his home life with his parents. Additionally, Mouse (guest star Samuel Hunt) causes tension as he looks to reenlist in the army, and Platt (Amy Morton) tells Tay (guest star Li Jun Li) that she has been reassigned to her original post. Also starring Jason Beghe, Jon Seda, Jesse Lee Soffer, Sophia Bush, Patrick Flueger, Elias Koteas, and LaRoyce Hawkins. Guest starring Yuri Sardarov, Nick Gehlfuss and Brendan Dooling.
10/25/2016 (10:00PM – 11:00PM) (Tuesday) : DAWSON AND CASEY DEAL WITH A VERY UNSETTLING POSSIBILITY – Casey (Jesse Spencer) enlists Susan Weller (guest Star Lauren Stamile) to help with an urgent personal matter. Severide (Taylor Kinney) receives an offer to travel luxuriously with rich party guy Travis Brenner (guest star Scott Elrod) and Stella (Miranda Rae Mayo) uses all her resources to help a sick street kid after saving him during a tunnel fire. Meanwhile, Otis (Yuri Sardarov) and Herrmann (David Eigenberg) discuss their concerns over Molly’s lack of customers. Jon Seda, S. Epatha Merkerson, and Marlyne Barrett guest star.
10/20/2016 (09:00PM – 10:00PM) (Thursday) : AN ACCIDENT AT THE SITE OF THE CHICAGO MARATHON LAUNCHES CHICAGO MED PERSONNEL WHO ARE ON THE SCENE INTO ACTION – A car accident that occurs at the Chicago Marathon leaves a victim in critical condition and tests the mettle of Dr. Halstead (Nick Gehlfuss), April (Yaya DaCosta) and her fourth-year medical resident brother Noah (guest star Roland Buck III), who must perform a difficult procedure in the field. A mother brings in her 8-year-old girl experiencing a sudden hearing loss and Dr. Manning (Torrey DeVitto) is left to tend to the case, which takes a complicated turn. Dr. Choi (Brian Tee) deals with Olga (guest star Betty Buckley), a woman who is malnourished, prompting him to bring in Dr. Charles (Oliver Platt) to help assess the case. Meanwhile, Goodwin (S. Epatha Merkerson) takes measures to get her personal life in order. Marlyne Barrett, Colin Donnell and Rachel DiPillo also star. Kara Killmer, Elias Koteas, Patti Murin and Jeff Hephner also guest star.
10/18/2016 (10:00PM – 11:00PM) (Tuesday) : 51 RESPONDS TO A DANGEROUS CALL AND KIDD IS FACED WITH A MAJOR DECISION – SCOTT ELROD GUEST STARS – Casey (Jesse Spencer) and Dawson (Monica Raymund) find themselves unexpectedly caught in the middle of a potential political mess. Stella (Miranda Rae Mayo) is left to make a serious decision about her ex-boyfriend. While responding to an auto accident, members of truck and squad find themselves in the middle of a dangerous situation. Elsewhere, Severide (Taylor Kinney) befriends a famous socialite (guest star Scott Elrod) that might distract him from his duties at 51, while Brett (Kara Killmer) and Mouch (Christian Stolte) set aside their writing differences for the greater good. Eamonn Walker, David Eigenberg, Yuri Sardarov, Joe Minoso and Steven R. McQueen also star. Oliver Platt and Colin Donnell guest star.
10/13/2016 (09:00PM – 10:00PM) (Thursday) : DR. CHARLES’ DAUGHTER ROBYN BECOMES THE NEWEST MEMBER OF THE HOSPITAL’S EPIDEMIOLOGY DEPARTMENT AND IS IMMEDIATELY CHALLENGED BY CASES OF A RARE INFECTION – Several patients are discovered to have the same rare infection, prompting Dr. Charles’ (Oliver Platt) daughter Robyn (guest star Mekia Cox), an epidemiologist, to be brought in to find the common link. Dr. Choi (Brian Tee) and Dr. Rhodes (Colin Donnell) work on an elderly man who is discovered to be very ill, but a conflict in how to best treat him develops between his son and his young girlfriend. Meanwhile, Dr. Reese (Rachel DiPillo) tries to help a young drug addict and Maggie (Marlyne Barrett) tends to a patient who is dear to her heart. S. Epatha Merkerson, Yaya DaCosta, Nick Gehlfuss and Torrey DeVitto also star. Jeff Hephner, Patti Murin and Ato Essandoh also guest star.
10/12/2016 (10:00PM – 11:00PM) (Wednesday) : A SHOOTING OUTSIDE OF A CONCERT LEADS TO A TANGLED WEB OF GANG-RELATED VIOLENCE. – When a car plows through a crowd of concert goers and gunfire erupts, Lindsay (Sophia Bush) and Ruzek (Patrick John Flueger) are on the scene. Unsure of the motive and concerned a terrorist group may be responsible, Voight (Jason Beghe) orders in Homeland security, customs and the F.B.I. to assist. At the same time, Burgess (Marina Squerciati) spots Atwater’s (LaRoyce Hawkins) brother, Jordan (guest star Ahmad Nicholas Ferguson), out where he shouldn’t be. The team use their connections to throughout the city to bring some peace to the community before more blood is shed. Also starring Jon Seda, Jesse Lee Soffer, Elias Koteas and Amy Morton. Guest starring Marlyne Barrett, Kenneth Tyrone Burns Jr., and Li Jun Li.
10/11/2016 (10:00PM – 11:00PM) (Tuesday) : SEVERIDE AND STELLA REMAIN IN JEOPARDY WHEN HER UNSTABLE EX-BOYFRIEND SURFACES ON THE SEASON FIVE PREMIERE – Severide (Taylor Kinney) and Stella (Miranda Rae Mayo) are on the lookout for a very unstable Grant (guest star Guy Burnet), who left Chicago Med without notice. Now that Dawson (Monica Raymund) is responsible for Louie, she questions her dangerous career path as a firefighter. Casey (Jesse Spencer) continues his work as Alderman but his relationship with his political consultant, Susan Weller (guest star Lauren Stamile), cools. Problems continue for Borrelli (Steven R. McQueen), who still blames Chief Boden (Eamonn Walker) for the death of his brother, and the situation reaches a boiling point. Meanwhile, Mouch (Christian Stolte) and Brett (Kara Killmer) start off on a new venture together. Jon Seda and Scott Elrod guest star.
10/05/2016 (10:00PM – 11:00PM) (Wednesday) : PLATT AND HER FATHER BECOME THE TARGETS OF A BRUTAL ASSAILANT. – When Platt (Amy Morton) goes to her father Robert’s (guest star Chelcie Ross) house for dinner, she warns him to be careful with his new girlfriend Natalie (guest star Lilia Vassileva). Following dinner, Platt is physically assaulted as she’s getting into her car and is rushed to Chicago Med. Voight (Jason Beghe), Lindsay (Sophia Bush) and Halstead (Jesse Lee Soffer) arrive at the hospital to investigate, and a concerned Mouch (guest star Christian Stolte) finds himself being questioned. Meanwhile, Antonio (Jon Seda) leads the rest of Intelligence at the scene as they look into previous threats against Platt, but his attention shifts when he is called into Robert’s townhouse and finds signs of an even more gruesome attack on Platt’s father. Also starring Antonio Dawson, Patrick Flueger, Elias Koteas, Marina Squerciati, and LaRoyce Hawkins. Guest starring Marlyne Barrett, Colin Donnell, Barbara Eve Harris and Gideon Emery.
10/06/2016 (09:00PM – 10:00PM) (Thursday) : FAMILY SECRETS ARE BROUGHT TO THE SURFACE WHEN MAGGIE’S SIBLING COMES TO TOWN – Dr. Manning (Torrey DeVitto) and fourth-year medical student Jeff Clarke (guest star Jeff Hephner) are forced to figure out a mystery illness when an Indonesian man who doesn’t speak English arrives at the hospital in dire straights. Maggie (Marlyne Barrett) takes Dr. Halstead (Nick Gehlfuss) to her family reunion where he meets her sibling Denise (guest star Alexandra Grey) and uncovers deep-rooted family secrets. Meanwhile, Dr. Rhodes (Colin Donnell) takes on a complicated heart surgery without consulting Dr. Latham (guest star Ato Essandoh) and Dr. Reese (Rachel DiPillo) and Dr. Charles (Oliver Platt) encounter a woman experiencing an unusual pregnancy. S. Epatha Merkerson, Yaya DaCosta and Brian Tee also star. Patti Murin also guest stars.
09/29/2016 (09:00PM – 10:00PM) (Thursday) : DR CHOI MENTORS A NAVY CORPSMAN AND TWO CASES FIND A SURPRISING CONNECTION – Dr. Manning (Torrey DeVitto) and Dr. Rhodes (Colin Donnell) separately treat complicated cases involving sick babies, only to uncover that the two cases could actually be intertwined. Elsewhere, Dr. Halstead (Nick Gehlfuss) and Dr. Charles (Oliver Platt) treat a homeless man with an upbeat disposition who sheds some valuable insight that prompts one of the doctors to learn a thing or two along the way. Dr. Choi (Brian Tee) has a Navy corpsman follow him for the day as they deal with the toll of gang violence in the city, while Dr. Reese (Rachel DiPillo) tries to understand the delicate balance required in her new position. S. Epatha Merkerson, Marlyne Barrett and Yaya DaCosta also star. Jeff Hephner and Patti Murin guest star.
09/28/2016 (10:00PM – 11:00PM) (Wednesday) : INTELLIGENCE SEARCHES FOR A MISSING WOMAN WHO DISAPPEARED FROM THE MOST DANGEROUS NEIGHBORHOOD IN DISTRICT 21. – When a call comes in reporting a car being stripped, Burgess (Marina Squerciati) and Tay (guest star Li Jun Li) respond and discover a badly beaten young man and his fiancé missing. Fearing a public relations nightmare Voight (Jason Beghe) and the team are on their best behavior as they search for answers and the missing woman. At the same time, Lindsay (Sophia Bush) surprises Halsted (Jesse Lee Soffer) with a big question. Commander Fogel (guest star Ian Bedford) berates Platt for going over his head to have Tay assigned to District 21. Also starring Jon Seda, Patrick John Flueger, Elias Koteas, LaRoyce Hawkins and Amy Morton. Guest starring Brian Tee, Samuel Hunt, Barbara Eve Harris and Sam Straley.